ABSTRACT
Objective To explore the effect of the combination of bandage contact lenses and ar-tificial tears on corneal epithelial injury , due to correction of blepharoptosis in patients .Methods Thirty-five patients (56 eyes) were included in this randomized controlled trial during May 2013 to May 2018 ,and randomly divided into observation group (combination of bandage contact lenses and artificial tears) and control group (combination of erythromycin eye ointment and artificial tears ) ,and followed up for 3 months .The corneal wound healing ,corneal fluorescent staining (FL ) ,Schirmer test (Slt) ,break-up time (BUT ) and the severity of eye pain were documented and compared by sta-tistical method .Results The scores of FL in the observation group were reduced (t = - 3 .211 , P <0 .05 ;t = - 3 .312 , P < 0 .05) ; the scores of eye pain in the observation group were reduced (t =- 7 .105 ,P < 0 .05 ; t = - 6 .543 , P < 0 .05) 7 days and 1 months postoperatively as compared with controls .The corneal wound healing of the observation group was improved during the same time peri-od (χ2 = 10 .286 ,P < 0 .05 ;χ2 = 4 .918 ,P < 0 .05) ,The BUT score of the observation group were im-proved (t = 3 .763 ,P < 0 .05 ;t = 3 .833 ,P < 0 .05) .However ,all above differences failed to reach sta-tistical significance 3 months postoperatively (the scores of FL ,t = 0 .328 ,P > 0 .05 ;the scores of eye pain ,t = - 1 .800 , P > 0 .05 ;the corneal wound healing ,χ2 = 1 .018 , P > 0 .05 ;the BUT score ,t =1 .661 ,P > 0 .05) .Conclusions The combination of bandage contact lenses and artificial tears is rec-ommended for the early use after correction of blepharoptosis ,to alleviate eye symptoms and promote corneal wound healing .
ABSTRACT
@#AIM: To investigate the clinical effect of vitamin A Palmitate Eye Gel combined with Tobramycin Eye Drops on corneal epithelial injury.<p>METHODS: Totally 80 patients(100 eyes)with corneal epithelial injury who came to our hospital from May 2015 to March 2016 were randomly divided into treatment group(50 eyes)and control group(50 eyes). The treatment group was treated with vitamin A Palmitate Eye Gel combined with Tobramycin Eye Drops, while the control group was treated with Tobramycin Eye Drops only. The curative effect of two groups was compared after 2wk and 4wk of treatment.<p>RESULTS: The cure rate was 80% and the effective rate was 94% in the treatment group. The cure rate was 70% and the effective rate was 78% in the control group. There was significant difference in the effective rate between the two groups(<i>P</i><0.05). The results of SⅠt and BUT test showed that the time of treatment group was significantly longer than that of control group(<i>P<</i>0.01). The score of symptoms and signs in the treatment group was significantly lower than that in the control group after 2wk of treatment(<i>P<</i>0.01), but there was no significant between treatment groups and control grouop after 4wk of treatment(<i>P></i>0.05).<p>CONCLUSION: Vitamin A Palmitate Eye Gel combined with Tobramycin Eye Drops can significantly improve dry eye symptoms and effectively shorten the healing time of corneal epithelium. It is an effective method to treat corneal epithelial injury.